Oxaloacetate

Reduce Mental Fatigue

A randomized placebo-controlled study showed that ME/CFS patients taking oxaloacetate experienced a >25% reduction in fatigue, with 40% of participants being “super responders” showing fatigue reductions up to 63%.

Boost Energy Levels

In an open-label study, oxaloacetate reduced mental and physical fatigue by up to 33% in ME/CFS patients and up to 46.8% in Long COVID patients over six weeks.

Enhance Overall Health

Oxaloacetate improves mitochondrial energy production, regulates blood glucose, and exhibits anti-cancer properties, supporting metabolic health and overall well-being.

Study #1: Oxaloacetate Reduces Fatigue by Over 25% in ME/CFS Patients

A preliminary 2024 randomized placebo-controlled study in ME/CFS patients found a statistically significant >25% average reduction in fatigue in those taking oxaloacetate, compared to a non-significant ~10% reduction in the placebo group. Additionally, 40% of participants were “super responders,” experiencing an average fatigue reduction of 63%.

RESTORE ME: A RCT of Oxaloacetate for Improving Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Study #2: Oxaloacetate May Reduce Fatigue by over 46.8% in Long COVID patients

An open-label study found oxaloacetate reduced mental and physical fatigue by up to 33% in ME/CFS patients and 46.8% in Long COVID patients over six weeks. Fatigue improvements were dose-dependent in ME/CFS patients.

Oxaloacetate Treatment for Fatigue in ME/CFS and Long COVID: A Non-Randomized Clinical Trial

Study #3: Natural Oxaloacetate Levels Are Significantly Lower in ME/CFS Patients

A Cornell study found significantly lower oxaloacetate levels in ME/CFS patients compared to healthy controls. This supports the role of oxaloacetate supplementation in improving mitochondrial energy production.

Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism

“It’s helped me. But I do build up a tolerance sometimes. Some people use it only for crashes. It can really help but it’s not a fix.”

ANDHarrison · reddit.com

“It helps me so much. Like, so much. I take the benagene for mecfs and take 1000mgs a day. I’ve noticed that it makes my energy envelope a little bit more stretchy, like I can push a little bit and be okay. I’ve been pacing religiously but it seems oxoloacetate increases the gains made from pacing, p…”

Thesaltpacket · reddit.com

“It has helped me! I’ve taken it for over 3 months at the recommended dose. When I had tried it at a lower dosage it did nothing. I’ve been able to stop using my wheelchair. I’ve been able to visit with friends. It’s the only thing that has helped me. The cost is immense. I’m fortunate to have the re…”

ANDHarrison · reddit.com