Guanfacine
ME/CFS · Long COVID · MCAS · Brain Fog · Memory · Cognitive Clarity
Pricing example
- $59
RTHM Safety Assessment Fee
Paid to RTHM. Every 90 days, only if approved.
- $15
Pharmacy cost
90-day supply + shipping
Expect higher medication cost during titration period
- $74
Estimated total for 90 days
With RTHM discount
Key benefits
Clearer Cognition
Guanfacine acts on the prefrontal cortex, improving memory, attention, and executive functioning to help clear brain fog and restore mental clarity.
Improved Focus
By strengthening neural connections, guanfacine helps maintain sustained attention and reduces distractibility, making daily tasks more manageable.
Blood Pressure Control
Guanfacine helps stabilize blood pressure by reducing sympathetic nervous system activity, beneficial for those with dysautonomia-related hypertension.
Is Guanfacine right for me?
Guanfacine is particularly effective for:
- Cognitive dysfunction (brain fog)
- Forgetfulness and loss of words
- Difficulty following conversations or completing tasks
- Inability to concentrate
- Hypertension
Patients with Long COVID, ME/CFS, or dysautonomia experiencing these symptoms may benefit from guanfacine.
What Does the Research Say?
Guanfacine's action on alpha-2A adrenergic receptors in the prefrontal cortex supports attention, working memory, and impulse control. Its promising off-label use includes conditions such as PTSD, traumatic brain injury, ME/CFS, and Long COVID.
"Guanfacine's mechanism of action in treating prefrontal cortical disorders: Successful translation across species"
Research & evidence
Guanfacine Supports Attention and Working Memory
Guanfacine's action on alpha-2A adrenergic receptors in the prefrontal cortex supports attention, working memory, and impulse control. Its promising off-label use includes conditions such as PTSD, traumatic brain injury, ME/CFS, and Long COVID.
Guanfacine's mechanism of action in treating prefrontal cortical disorders: Successful translation across species
View StudyGuanfacine May Alleviate Cognitive Dysfunction by Improving Blood Flow
Guanfacine has shown potential to alleviate cognitive dysfunction by improving blood flow, modulating brain activity, and addressing the physical and mental fatigue often associated with complex illnesses.
Guanfacine
View StudyGuanfacine + N-Acetylcysteine for ME/CFS Brain Fog
A novel treatment using guanfacine combined with N-acetylcysteine (GXN) was developed for ME/CFS brain fog. The three-patient case report indicated improvement in all participants with good tolerability.
Guanfacine Plus N-Acetylcysteine for the Treatment of Cognitive Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Open-Label, Proof of Concept Trial (GXN in ME/CFS)
View Study
What people say
“I was able to go back to school, work full time. I didn't crash, didn't have PEM. After getting to 1mg I had energy and mental stamina that allowed me to use my brain for more than an hour a day!”
u/No_Understanding9301 · reddit.com
“Brain fog improved from 4 to 7. I never thought my brain fog would improve. All because of guanfacine.”
u/GlitteringAutist · reddit.com
“I had moderate cfs/me with moderate brain fog… once I changed the dose, the brain fog went away completely!”
u/ErmintrudeFanshaw · reddit.com